Table 3.
Functions of m6A RNA modification in lipid metabolism
| Regulators | Function | Mechanism | Reference |
|---|---|---|---|
| METTL3 | METTL3 decreases PPARα m6A abundance and increases PPARα mRNA half-life and expression, reducing lipid accumulation | mRNA stability | 77 |
| YTHDF2/FTO | promotes adipose differentiation | gene expression | 78 |
| YTHDF1 | YTHDF1 promotes mitochondrial carrier homology 2 (MTCH2) translation to regulate adipogenesis | translation | 79 |
| FTO/YTHDF2 | FTO enhances expression of JAK2 and YTHDF2 directly targets JAK2 and accelerates mRNA decay | gene expression, mRNA decay | 80 |
| FTO | FTO controls splicing of RUNX1T1 mRNA by regulating m6A levels, regulating adipogenesis | mRNA splicing | 82 |
| FTO | FTO binds to Angptl4 to encode an adipokine that stimulates intracellular lipolysis in adipocytes | translation | 84 |
| ime4Δ | ime4Δ (yeast m6A methyltransferase gene deletion) cells showed a significant decrease in expression of the key genes involved in peroxisomal β-oxidation in yeast | gene expression | 85 |
| YTHDF1 | facilitates translation of Wnt signaling effectors TCF7L2 and TCF4, which are required for maintenance of intestinal stem cells (ISCs) during regeneration and tumorigenesis | translation | 86 |