Table 2.
Analysis of the acute toxicity of formulations L and F in C57Bl/6 mice. Organ indexes of mice on day 14 after a single intravenous (IV) administration of formulations L or F or saline (control).
| Group | Average Weight, g | Liver Index 1 | Renal Index 1 | Spleen Index 1 |
|---|---|---|---|---|
| Control | 22.4 ± 0.2 | 5.8 ± 0.2 | 0.7 ± 0.07 | 0.5 ± 0.01 |
| L (1 TD 2) | 23.2 ± 0.5 | 5.9 ± 0.2 | 0.8 ± 0.08 | 0.4 ± 0.01 |
| L (5 TD 2) | 22.6 ± 0.3 | 5.8 ± 0.1 | 0.7 ± 0.04 | 0.4 ± 0.01 |
| F (1 TD 2) | 24.0 ± 0.6 | 4.8 ± 0.3 | 0.6 ± 0.03 | 0.3 ± 0.02 |
| F (5 TD 2) | 25.6 ± 0.6 | 5.6 ± 0.3 | 0.7 ± 0.03 | 0.3 ± 0.02 |
1 Organ indexes were calculated according to the following formula: organ index = [organ weight (g)/body weight (g)] × 100%.; 2 TD, therapeutic dose; 1 TD corresponds to 1.5 nmol/g of liposomes.