Table 3.
Analysis of the chronic toxicity of formulation L in C57Bl/6 mice. Organ indexes of mice on day 60 after four intravenous (IV) administrations of formulation L or saline buffer (control).
| Group | Average Weight, g | Liver Index 1 | Renal Index 1 | Spleen Index 1 | Heart Index 1 | Lung Index 1 |
|---|---|---|---|---|---|---|
| Control | 20.7 ± 0.5 | 5.5 ± 0.1 | 0.7 ± 0.04 | 0.4 ± 0.02 | 0.5 ± 0.03 | 1.2 ± 0.06 |
| L (1 TD 2) | 21.0 ± 0.4 | 5.3 ± 0.1 | 0.7 ± 0.02 | 0.4 ± 0.02 | 0.6 ± 0.04 | 1.2 ± 0.1 |
| L (2 TD 2) | 20.9 ± 0.3 | 5.1 ± 0.2 | 0.6 ± 0.03 | 0.4 ± 0.03 | 0.6 ± 0.02 | 1.2 ± 0.04 |
1 Organ indexes were calculated according to the following formula: organ index = [organ weight (g)/body weight (g)] × 100%.; 2 TD, therapeutic dose; 1 TD corresponds to 1.5 nmol/g of liposomes.