Table 5.
Morphometric analysis of epidermoid carcinoma KB-8-5 tumor tissue without treatment (control), after polychemotherapy (PCHT), and after siMDR/F treatment followed by PCHT (PCHT + siMDR/F).
| Morphologic Parameters of Tumor | Control | PCHT | PCHT + siMDR/F | PCHT + siScr/F |
|---|---|---|---|---|
| Vv 1 normal tissue, % | 33.1 ± 2.9 | 45.3 ± 3.6 * | 77.7 ± 3.4 *,# | 52.4 ± 3.9 * |
| Vv necrosis, % | 33.7 ± 2.1 | 26.5 ± 2 * | 14.9 ± 2.5 *,# | 24.9 ± 4.3 * |
| Vv inflammation, % | 33.0 ± 2.6 | 27.7 ± 3.1 | 7.3 ± 1.1 *,# | 22.8 ± 1.8 * |
| Nv 2 mitosis | 2.2 ± 0.2 | 2.2 ± 0.3 | 1.4 ± 0.2 *,# | 2.4 ± 0.3 |
| Nv caspase-3 positive cells |
7.1 ± 1.8 | 16.2 ± 3.7 * | 23.9 ± 0.5 *,# | 12.9 ± 1 * |
1 Vv—the volume density of the studied histological structure represents the volume fraction of tissue occupied by this compartment.; 2 Nv—the numeric density of the studied histological structure indicates the number of particles in the unit tissue volume.; * Statistically significant difference relative to KB-8-5 without treatment (control), p ≤ 0.05.; # Statistically significant difference relative to PCHT group, p ≤ 0.05.