Figure 3.

Retinal pigment epithelium plumes evolve over time. (A–E) Tracked optical coherence tomography B-scans of five different eyes with AMD are shown with individualized colored frames and scale bars. Numbers in the lower-right corners indicate time elapsed in months since the baseline visit at 0 months. (A1–A4) HRF overlie a drusenoid pigment epithelial detachment that collapsed at 12 months. HRF evolve into a comma plume before disappearing into complete outer retinal atrophy.⁹ (B1–B6) A curvilinear plume evolves into a vitelliform plume, which collapses, leaving atrophy and degenerative cysts. (C1–C3) A comma-type plume evolves into HRF upon drusen collapse. (D1–D3) Of two thread plumes at baseline, one (left) becomes curvilinear at 3 months and persists through drusen collapse and incomplete RPE and outer retinal atrophy at 13 months. Thread plume at the right has disappeared at 13 months. (E1–E2) Two thread plumes evolve into a comma plume as an RPE elevation appears. This eye also has an epiretinal membrane.