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. 2021 Jul 30;11(8):768. doi: 10.3390/life11080768

Figure 4.

Figure 4

PRMT7 SAM-binding pocket comparison and occupancy by the inhibitory compound SGC 8158. (A) Comparison of SAM-binding domains of modules N and C. Overlay of module-N (in green) and module-C (in grey) SAM-binding domains of MmPRMT7 in complex with SAH (yellow). (B) Close-up view of module-N SAM-binding domain in complex with SGC8158 chemical probe (cyan) (PDB ID: 6OGN). The SAM-binding domains for both MmPRMT7-SGC8158 and TbPRMT7-SAH in complex with H4 peptide (PDB ID: 4M38) were superimposed to show the SGC8158 binding mode relative to SAH (yellow) and H4 peptide (magenta).