Table 1.
Selected PRMT7 substrates in cells.
| Substrate | R Methylation Sites | Function, Disease Relevance, Reference |
|---|---|---|
| DVL3 | 271, 342, 614 | DVL3 localization, wnt signaling, cancer [30] |
| EIF2S1 (EIF2 alpha) | 55 | Translation arrest, stress granule regulation, [31] |
| G3BP2 | 432, 438, 452, 468 | Wnt signaling, cancer, [32] |
| GLI2 | 225/227 | Cell senescence, [33] |
| Histone H4, H2A | H4R3, H2AR3 | Gene expression, [23,24,25,26,27] |
| HNRNPA1 | 194, 206, 218, 225 | Splicing, [28] |
| HSP70 | 469 | Stress response, [13] |
| NALCN | 1653 | Neuronal excitability, [34] |
| MAVS | 52 | Viral infection, [35] |
| MRPS23 | 21 | Oxidative phosphorylation, cell invasion, cancer [36] |
| P38MAPK | 70 | Myoblast differentiation, [37] |
| PRMT7 | 531 | Cell migration, cancer [16] |