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Large (Lg) airways express high amounts of ATP12A but small (Sm) airways express lower amounts of ATP12A. (A and C) ATP12A immunostaining (brown coloration) of human and pig Lg airway shows intense staining at apical surface of epithelial cells (arrows) and immunostaining is also seen in submucosal glands (arrowheads). Scale bars: A, 75 μm; C, 25 μm. (B and D) ATP12A immunostaining is absent in Sm airways. Scale bars: B, 75 μm; D, 25 μm.
