Table 1.
GO Term Enrichment for Genes Differentially Expressed on Day 7 in COPD HBEC Compared with Normal HBEC after Repopulation on COPD Bronchial Scaffolds
| GO Biological Process | Fold Enrichment | FDR |
|---|---|---|
| Cilium organization (GO:0044782) | 2.7 | 1.4 × 10−16 |
| Cilium assembly (GO:0060271) | 2.6 | 5.6 × 10−15 |
| Plasma membrane–bounded cell projection assembly (GO:0120031) | 2.3 | 2.4 × 10−13 |
| Cell projection assembly (GO:0030031) | 2.3 | 3.6 × 10−13 |
| Cell projection organization (GO:0030030) | 1.6 | 2.1 × 10−7 |
| Microtubule-based process (GO:0007017) | 1.8 | 2.8 × 10−7 |
| Microtubule bundle formation (GO:0001578) | 3.5 | 3.5 × 10−7 |
| Plasma membrane–bounded cell projection organization (GO:0120036) | 1.6 | 6.4 × 10−7 |
| Organelle assembly (GO:0070925) | 1.7 | 7.5 × 10−7 |
| Axoneme assembly (GO:0035082) | 4.1 | 8.1 × 10−7 |
Definition of abbreviations: COPD = chronic obstructive pulmonary disease; FDR = false discovery rate; GO = Gene Ontology; HBEC = human bronchial epithelial cells; RNA-Seq = RNA sequencing.
Shown are the GO biological process terms for which there is an overrepresentation among the differentially expressed genes relative to the reference list, which consisted of all GO-annotated genes that were detected in at least one RNA-Seq sample. Shown are the 10 terms with the lowest FDR for each analysis.