Table 3.
GO Term Enrichment for Genes Differentially Expressed in COPD HBEC on COPD Bronchial Scaffolds Compared with Normal Bronchial Scaffolds after 7 Days of Differentiation
| GO-Slim Biological Process | Fold Enrichment | FDR |
|---|---|---|
| Chromosome segregation (GO:0007059) | 3.4 | 4.2 × 10−5 |
| DNA metabolic process (GO:0006259) | 2.1 | 8.9 × 10−5 |
| DNA replication (GO:0006260) | 2.7 | 1.2 × 10−4 |
| Regulation of cell cycle (GO:0051726) | 2.5 | 2.0 × 10−4 |
| Cellular process (GO:0009987) | 1.1 | 5.9 × 10−4 |
| Cell cycle (GO:0007049) | 1.6 | 6.5 × 10−4 |
| Metabolic process (GO:0008152) | 1.2 | 4.4 × 10−3 |
| Translation (GO:0006412) | 2.0 | 9.1 × 10−3 |
| Cell proliferation (GO:0008283) | 2.8 | 1.6 × 10−2 |
| DNA recombination (GO:0006310) | 3.1 | 1.6 × 10−2 |
| Biosynthetic process (GO:0009058) | 1.3 | 1.9 × 10−2 |
| Phosphate-containing compound metabolic process (GO:0006796) | 1.3 | 2.1 × 10−2 |
| DNA repair (GO:0006281) | 2.0 | 2.9 × 10−2 |
| Mitosis (GO:0007067) | 1.8 | 3.8 × 10−2 |
| Meiosis (GO:0007126) | 2.6 | 3.9 × 10−2 |
Shown are the GO-slim biological process terms for which there is an overrepresentation among the differentially expressed genes relative to the reference list, which consisted of all GO-annotated genes that were detected in at least one RNA-Seq sample. Shown are the 15 terms with the lowest FDR.