. 2021 Aug 13;7(8):657. doi: 10.3390/jof7080657

Table 6.

Univariate analysis of the treatment response and overall outcomes among patients with isolated pulmonary cryptococcosis.

Factors		N ^#	Disease Control Rate	p Value *	N ^$	Recurrence or Death from any Cause	p Value *
Age	<65 years	128	125 (97.7)	0.071	188	17 (9.0)	0.008
Age	≥65 years	71	65 (91.5)	0.071	91	19 (20.9)	0.008
Gender	Female	84	82 (97.6)	0.307	117	11 (9.4)	0.152
Gender	Male	115	108 (93.9)	0.307	162	25 (15.4)	0.152
Smoking status	Non-smokers	145	141 (97.2)	0.028	207	24 (11.6)	0.269
Smoking status	Smokers	42	37 (88.1)	0.028	58	10 (17.2)	0.269
Comorbidities	No	72	71 (98.6)	0.008	111	4 (3.6)	<0.001
	Single	84	82 (97.6)		113	15 (13.3)
	Multiple	43	37 (86.0)		55	17 (30.9)
Blood CrAg test	<1:128	136	134 (98.5)	0.005	193	18 (9.3)	<0.010
Blood CrAg test	≥1:128	62	55 (88.7)	0.005	68	15 (22.1)	<0.010
Lung involvement	Single lobe	113	110 (97.3)	0.179	170	19 (11.2)	0.263
Lung involvement	Multilobar	86	80 (93.0)	0.179	99	16 (16.2)	0.263
Cavitation	No	175	168 (96.0)	0.297	238	30 (12.6)	0.572
Cavitation	Yes	24	22 (91.7)	0.297	31	5 (16.1)	0.572
Single nodule or mass	No	185	176 (95.1)	1.000	224	30 (13.4)	0.811
Single nodule or mass	Yes	14	14 (100.0)	1.000	42	5 (11.1)	0.811

CrAg, cryptococcal antigen.* By Fisher’s exact test. ^# Analysis of disease control; excludes patients without treatment, with surgical resection, loss of follow-up, and not-cryptococcosis-related death before complete treatment. ^$ Analysis of recurrence of death; excludes patients with loss of follow-up.