Table 4.

in silico ADME study for peptides 6 and 11.

Peptides	Lipophilicity		Drug-Likeness		Pharmacokinetics
	TPSA (Å)	CLogP (o/w)	Bioavailability Score	Lipinski Filter	GIA	P-gp Substrate	CYP3A4 Inhibitor
6	132.37	2.59	0.55	Yes (1)	high	yes	no
11	148.16	2.46	0.55	Yes (1)	low	yes	yes

Abbreviations: CLogP (o/w), logarithm of compound partition coefficient between n-octanol and water; CYP3A4, cytochrome P450 3A4; GIA, gastrointestinal absorption; Lipinski filter (with number of violations in bracket); TPSA, topological polar surface area.