Table 2.

Studies evaluating the effect of arginine supplementation on wound healing and reported outcomes.

Study	Duration	Patient Population	n	Dosage	Control Group	Outcome
Barbul et al. [59]	14 days	Surgery	36	24.8 g Arg	Not supplemented	↑ Collagen deposition, ↑ Wound-breaking strength, ↑ Lymphocyte mitogenesis
Nussbaum [64]	14 days	Surgery	30	17 g Arg	Not supplemented	↑ Collagen synthesis, ↑ T-cell-mediated immune function, ↑ IGF-1
Debats et al. [65]	5 days	Surgery	35	30 g intravenous Arg	Isonitrogenous solution	Citrulline, ornithine and NO levels, Angiogenesis, Reepithelialisation
Sigal et al. [66]	7 days	Abdominal surgery	30	14.7 g intravenous Arg	Isonitrogenous solution	Lymphocyte proliferation, NO
Langkamp-Henken et al. [60]	4 weeks	Elderly people with pressure ulcers	33	0, 8.5 or 17 g Arg	Not supplemented	Lymphocyte proliferation, NO, IL-2

Arg: arginine; Cu: copper; Gln: glutamine; HBM: β-hydroxy-β-methylbutyrate; IGF-1: insulin-like growth factor; NO: nitric oxide; P: phosphorous; RME: resting metabolic expenditure; Zn: zinc; ↑: increases; does not increase or decrease.