Figure 1.

PK model used to assess the hepatobiliary disposition of [¹¹C]tariquidar, [¹¹C]erlotinib, and [¹¹C]elacridar. CL₁ (mL/min) represents the hepatic uptake clearance, and k₂ and k₃ (min⁻¹) are the rate constants describing the transfer of radioactivity from liver to the sink compartment (blood) and from liver to excreted bile (intestine volume of interest), respectively. The model was modified from a previously published model (Adapted from [28], AAPS, 2019). IF: input function; VOI: volume of interest.