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Sagittal PET summation images (0–60 min) of the head obtained after i.v. injection of either [11C]tariquidar, [11C]erlotinib, or [11C]elacridar in one representative wild-type, Abcb1a/b(−/−), Abcg2(−/−), and Abcb1a/b(−/−)Abcg2(−/−) mouse. Radioactivity concentration is expressed as percent of injected dose per milliliter (%ID/mL). Brain (B) is labeled with white arrows and red dashed-line areas.
