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. 2021 Aug 18;13(8):1286. doi: 10.3390/pharmaceutics13081286

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Initial brain uptake clearance (CL_uptake,brain) of [¹¹C]tariquidar, [¹¹C]erlotinib, and [¹¹C]elacridar determined with integration plot analysis in wild-type, Abcb1a/b^(−/−), Abcg2^(−/−), and Abcb1a/b^(−/−)Abcg2^(−/−) mice. **** p ≤ 0.0001, one-way ANOVA followed by a Dunnett’s multiple comparison test against the reference group (wild-type).