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Rate constant (k3) representing the transfer of radioactivity from liver to excreted bile (intestinal region of interest) obtained with the compartmental model for [11C]tariquidar, [11C]erlotinib, and [11C]elacridar in wild-type, Abcb1a/b(−/−), Abcg2(−/−), and Abcb1a/b(−/−)Abcg2(−/−) mice. ** p ≤ 0.01, *** p ≤ 0.001, one-way ANOVA followed by a Dunnett’s multiple comparison test against the reference group (wild-type).
