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. 2021 Aug 28;21:457. doi: 10.1186/s12935-021-02155-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — DLGAP5 expression is up-regulated in HCC cells and promotes HCC cells proliferation and invasion. a DLGAP5 expression in human HCC cell lines analyzed by real-time PCR. b DLGAP5 expression in human HCC cell lines analyzed by western blotting. c Proliferation of PLC/PRF5-DLGAP5, Hep3B-shDLGAP5 cells and control cells was examined by colony formation assays. d Transwell invasion assay were subjected to detect the migration and invasion capacity of DLGAP5-interfered cells. *P < 0.05; **P < 0.01 and ***P < 0.001 based on the Student test. Error bars, standard deviation