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In the GABA shunt, GABA is synthesized from glutamate in a process catalyzed by GAD. GABA is metabolized by GABA-T into succinate semi-aldehyde, which is then reduced to gamma-hydroxybutyrate or oxidized to succinate and eventually converted to CO2 and water via the TCA cycle. GAD, glutamatic acid decarboxylase; GABA-T, GABA transaminase; SSA, succinic semialdehyde; SSA-DH, succinic semialdehyde dehydrogenase; TCA cycle, tricarboxylic acid cycle. Green, enzymes; Orange, cofactor.
