Figure 1.

Steps to follow to achieve TFR from diagnosis of CML, detection of individual mutations, treatment of TKI to stable deep molecular remission (DMR), and then discontinuation of treatment (TFR) with 50% success or molecular relapse, prompting re-initiation of treatment to re-attain DMR and eventually make a second attempt to discontinuation treatment (2nd TFR). A scheme to include younger patients with low- to medium-risk disease and women who wish to become pregnant for whom TFR has a high priority.