Table 3.

Physicochemical properties of besifloxacin.

Properties	Besifloxacin	Besifloxacin Hydrochloride	Ref.
Chemical name (IUPAC)	{7-[(3R)-3-aminohexahydro-1H-azepin-1-yl]-8- chloro-1-clyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid}	(+)-7-[(3R)-3-aminohexahydro-1H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride	[46] [97]
Chemical formula	C19H21ClFN3O3	C19H21ClFN3O3·HCl	[97]
Molecular weight	393.8 g/mol	430.40 g/mol	[116] [117]
Aspect	Not available	White to pale yellowish-white powder; white to light brown	[97,117,118]
Solubility	Insoluble in water 0.143 mg/mL (predicted values)	2 mg/mL (DMSO 1)	[46,106,116,118]
LogP	0.7; 0.54	Not available	[106]
pKa	6.0–7.0; 5.64—strongest acidic, 9.67—strongest basic (predicted values); 5.45 (carboxyl), 9.84 (amino) (calculated)	Not available	[46,61,106,116]
Melting point	Not available	Over 210 °C; 270.04 °C	[117,119]
Storage	Not available	At refrigerator; −20 °C	[117,118]

¹ DMSO—Dimethyl sulfoxide.