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. 2021 Aug 22;26(16):5089. doi: 10.3390/molecules26165089

Figure 5.

Figure 5

The iNOS inhibitor R-MRI-1867 decreases serum endotoxin level in acutely alcohol-intoxicated mice. Mice received S-MRI-1867 10 mg/kg (S) or R-MRI-1867 10 mg/kg (R) or vehicle (veh) by oral gavage (time 0), followed by intragastric administration of 6 g/kg ethanol (30% w/v; EtOH) or saline at 30 min. Endotoxin was measured in the serum obtained from the portal vein 1 h after the acute alcohol challenge. Results are expressed as mean ± s.e.m. * p < 0.05, ** p < 0.01, compared with vehicle in alcohol-treated group (one-way ANOVA followed by Dunnett’s post hoc test), # p < 0.05, compared with saline-treated mice.