Figure 1.

Inflammasome signaling cascade and inhibitors. The first step, termed as priming, leads to activation of nuclear factor kappa light chain enhancer of activated B cells (NF-kB) and various transcription factors following the involvement of pattern recognition receptors (PRRs) (TLR4). This engenders the expression of NLRP3 as well as pro-IL-1β. The second step comprises of signal (or trigger) detection that in turn governs the triggering mechanism of NLRP3 and the subsequent generation of the inflammasome.