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. 2021 Jul 27;13(8):1152. doi: 10.3390/pharmaceutics13081152

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of the action of ion release from MBG-75S on differentiation of MC3T3-E1 pre-osteoblasts in monoculture (MC3T3 MBG T) and in coculture with RAW 264.7 macrophages (MC3T3 RAW MBG T). For the coculture, MC3T3-E1 pre-osteoblasts were seeded on glass coverslips introduced into 6-well culture plates and RAW 264.7 macrophages were seeded around each coverslip. Additionally, 1 mg/mL of MBG-75S was deposited on transwell inserts, allowing the ions to diffuse through the pores in both monocultures and cocultures. Alkaline phosphatase activity (ALP) was evaluated as a specific marker of in vitro osteogenesis after 10 days of culture. Statistical significance: *** p < 0.005.