Table 1.
Anthropometric, hemodynamic, and biohumoral characteristics, stratified according to the presence or absence of renal dysfunction (eGFR < 60 mL/min/1.73 m2) at baseline.
| All | Renal Dysfunction | No Renal Dysfunction | p | |
|---|---|---|---|---|
| (n = 707) | (n = 157) | (n = 550) | ||
| eGFR, mL/min/1.73 m2 | 79.7 ± 26.1 | 48.3 ± 8.5 | 88.6 ± 22.2 | <0.0001 |
| Gender, m/f | 367/340 | 88/69 | 279/271 | 0.239 |
| Age, years | 61.8 ± 9.9 | 67.4 ± 5.7 | 60.2 ± 10.3 | <0.0001 |
| BMI, kg/m2 | 29.2 ± 5.8 | 29.1 ± 5.9 | 29.2 ± 5.7 | 0.859 |
| SBP, mmHg | 141.2 ± 15.4 | 143.5 ± 18.6 | 140.5 ± 14.3 | 0.065 |
| DBP, mmHg | 82.7 ± 10.5 | 82.8 ± 11.3 | 82.7 ± 10.3 | 0.970 |
| Pulse pressure, mmHg | 58.4 ± 14.3 | 60.7 ± 16.1 | 57.8 ± 13.9 | 0.038 |
| Fasting glucose, mg/dL | 103.7 ± 22.8 | 115.5 ± 34.4 | 100.4 ± 16.9 | <0.0001 |
| Fasting insulin, mU/mL | 12.6 ± 5.8 | 15.8 ± 8.5 | 11.7 ± 4.5 | <0.0001 |
| HOMA | 3.2 ± 1.9 | 4.4 ± 3.1 | 2.9 ± 1.2 | <0.0001 |
| Total cholesterol, mg/dL | 198.8 ± 46.1 | 200.9 ± 40.3 | 198.1 ± 47.6 | 0.489 |
| LDL-cholesterol, mg/dL | 117.1 ± 35.6 | 117.4 ± 36.3 | 117.1 ± 35.4 | 0.919 |
| HDL-cholesterol, mg/dL | 48.9 ± 14.8 | 45.2 ± 11.8 | 50.1 ± 15.4 | <0.0001 |
| Triglycerides, mg/dL | 137.3 ± 87.9 | 141.2 ± 97.8 | 136.1 ± 84.9 | 0.554 |
| Creatinine, mg/dL | 1.01 ± 0.2 | 1.21 ± 0.4 | 0.96 ± 0.1 | <0.0001 |
| Uric acid, mg/dL | 5.5 ± 2.5 | 6.9 ± 2.4 | 5.1 ± 2.3 | <0.0001 |
| hs-CRP, mg/dL | 2.9 ± 2.1 | 3.6 ± 2.4 | 2.7 ± 1.9 | <0.0001 |
| Pre-bronchodilator FEV1, % | 82.3 ± 22.2 | 81.7 ± 22.3 | 86.2 ± 21.6 | 0.022 |
| FEV1/FVC | 0.61 ± 0.07 | 0.60 ± 0.07 | 0.62 ± 0.06 | 0.013 |
Abbreviations: eGFR, estimated glomerular filtration rate; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HOMA, homeostatic model assessment; LDL, low-density lipoprotein; HDL, high-density lipoprotein; hs-CRP, high-sensitivity C-reactive protein; FEV1, forced expiratory volume in the 1st second; FVC, forced vital capacity.