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. 2021 Aug 4;11(8):513. doi: 10.3390/metabo11080513

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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RNA-seq analysis of INS-1 cells overexpressing hsTCF19 identifies upregulated genes that form a tight node of interconnected genes with roles in viral, immune, and interferon response pathways (A) PANTHER overrepresentation test for GO biological processes on >2- fold upregulated genes show enrichment for genes involved in viral responses (red), regulation of immune response processes (blue), regulation of cytokines (purple), and antigen presentation (green). Additionally, other processes such as regulation of double strand break repair, apoptotic signaling pathway in response to ER stress, and positive regulation of NF-κB signaling were also overrepresented (black) (FDR < 5%). (B) STRING analysis on differentially expressed genes with >2-fold upregulation shows tightly interconnected network of genes.

RNA-seq analysis of INS-1 cells overexpressing hsTCF19 identifies upregulated genes that form a tight node of interconnected genes with roles in viral, immune, and interferon response pathways (A) PANTHER overrepresentation test for GO biological processes on >2- fold upregulated genes show enrichment for genes involved in viral responses (red), regulation of immune response processes (blue), regulation of cytokines (purple), and antigen presentation (green). Additionally, other processes such as regulation of double strand break repair, apoptotic signaling pathway in response to ER stress, and positive regulation of NF-κB signaling were also overrepresented (black) (FDR < 5%). (B) STRING analysis on differentially expressed genes with >2-fold upregulation shows tightly interconnected network of genes.