Figure 2.

Structure of the cis-acting elements present in EV-D genomes: 5′ CL (A), 5′ IRES with its respective topology tree (B), 3′ UTR (C), and cre (D). Contemporary EV-D68, EV-D68 Fermon, EV-D94, EV-D70, and EV-D111 were included. The RNA fragments were extracted using the AliView [17] sequence alignment editor and then were simultaneously folded and aligned using LocARNA from Freiburg RNA tools. The sequence alignment of the different regions is available in Supplementary Figure S1.