Table 3.
Interactions determined by the checkerboard method between selected plant extracts (A4/2 and A5/1) and selected synthetic substances (amoxicillin, 3-bromopyruvate, and sertraline) against H. pylori 8064.
| Tested Combination | MIC (µg/mL) | FICI (Outcome) | |||||
|---|---|---|---|---|---|---|---|
| Selected Plant Extract | Selected Synthetic Compound | ||||||
| Alone | Combination | Fold Change | Alone | Combination | Fold Change | ||
| A4/2 + AMX | 128 | 32 | 4 | 0.06 | 0.015 | 4 | 0.5 (synergistic) |
| A4/2 + 3-BP | 128 | 32 | 4 | 128 | 32 | 4 | 0.5 (synergistic) |
| A4/2 + SER | 128 | 32 | 4 | 2 | 1 | 2 | 0.75 (additive) |
| A5/1 + AMX | 64 | 16 | 4 | 0.06 | 0.015 | 4 | 0.5 (synergistic) |
| A5/1 + 3-BP | 64 | 16 | 4 | 128 | 32 | 4 | 0.5 (synergistic) |
| A5/1 + SER | 64 | 16 | 4 | 2 | 1 | 2 | 0.75 (additive) |
Abbreviations: AMX, amoxicillin; 3-BP, 3-bromopyruvate; SER, sertraline; MIC, minimal inhibitory concentration; FICI, fractional inhibitory concentration index.