Table 4.
Safety analysis of control and test at baseline, 8 weeks (mean ± SD).
| Control (n = 52) |
Test (n = 52) |
p-Value | ||||
|---|---|---|---|---|---|---|
| n | Mean ± SD | n | Mean ± SD | |||
| WBC (103/μL) |
Baseline | 52 | 6.37 ± 1.50 | 52 | 5.91 ± 1.48 | 0.0885 # |
| 8 weeks | 50 | 6.16 ± 1.42 | 48 | 6.03 ± 1.65 | 0.1850 # | |
| p-value | 0.2574 ** | 0.3750 @ | ||||
| RBC (106/μL) |
Baseline | 52 | 4.48 ± 0.39 | 52 | 4.55 ± 0.43 | 0.7158 # |
| 8 weeks | 50 | 4.48 ± 0.38 | 48 | 4.61 ± 0.40 | 0.0483 * | |
| p-value ** | 0.8040 | 0.0101 | ||||
| Hb (g/dL) |
Baseline | 52 | 13.50 ± 1.05 | 52 | 13.94 ± 1.22 | 0.1361 # |
| 8 weeks | 50 | 13.54 ± 1.06 | 48 | 14.18 ± 1.18 | 0.0381 * | |
| p value ** | 0.8624 | 0.0020 | ||||
| Hct (%) |
Control | 52 | 40.27 ± 3.04 | 52 | 41.06 ± 3.28 | 0.3907 # |
| Test | 50 | 40.30 ± 3.07 | 48 | 41.83 ± 3.39 | 0.0120 * | |
| p-value ** | 0.8583 | 0.0003 | ||||
| PLT (103/μL) |
Baseline | 52 | 255.69 ± 54.75 | 52 | 269.40 ± 54.23 | 0.1340 # |
| 8 weeks | 50 | 253.74 ± 52.71 | 48 | 268.27 ± 54.60 | 0.8496 * | |
| p-value ** | 0.4001 | 0.3227 | ||||
| AST(GOT) (IU/L) |
Baseline | 52 | 19.38 ± 7.95 | 52 | 21.00 ± 8.81 | 0.0356 # |
| 8 weeks | 50 | 20.18 ± 10.53 | 48 | 21.06 ± 8.38 | 0.9517 # | |
| p-value | 0.9147 @ | 0.7794 ** | ||||
| ALT(GPT) (IU/L) @ |
Baseline | 52 | 16.23 ± 9.02 | 52 | 19.81 ± 16.81 | 0.1501 # |
| 8 weeks | 50 | 18.36 ± 13.04 | 48 | 18.85 ± 14.80 | 0.1332 # | |
| p-value | 0.3130 | |||||
| Glucose (mg/dL) @ |
Baseline | 52 | 94.69 ± 12.52 | 52 | 97.56 ± 17.03 | 0.5195 # |
| 8 weeks | 50 | 95.56 ± 12.69 | 48 | 95.00 ± 11.16 | 0.2431 # | |
| p-value | 0.3297 | 0.4144 | ||||
| BUN (mg/dL) |
Baseline | 52 | 12.27 ± 3.15 | 52 | 12.78 ± 3.58 | 0.6419 # |
| 8 weeks | 50 | 11.88 ± 2.77 | 48 | 12.44 ± 3.42 | 0.8643 * | |
| p-value ** | 0.3753 | 0.5011 | ||||
| Creatinine (mg/dL) |
Baseline | 52 | 0.74 ± 0.13 | 52 | 0.77 ± 0.16 | 0.5715 # |
| 8 weeks | 50 | 0.73 ± 0.14 | 48 | 0.76 ± 0.15 | 0.8625 * | |
| p-value ** | 0.5020 | 0.6074 |
Boldface denotes statistical significance (p < 0.05). * Compared between groups; p-value for Two sample t-test, # compared between groups; p-value for Wilcoxon rank-sum test, ** compared within group; p-value for paired t-test, @ compared within group; p-value for Wilcoxon signed-rank test. WBC, white blood cell; RBC, red blood cell; Hb, hemoglobin; Hct, hematocrit; PLT, platelet; AST, aspartate aminotransferase; ALT, alanine transaminase; BUN, blood urea nitrogen.