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Possible mechanisms from clinical studies targeting mTOR in PC pathogenesis. Abbreviations: AR = androgen receptor; CTC = circulating tumor cell; mTOR = mammalian target of rapamycin; PTEN = phosphatase and tensin homolog; 4EBP1 = 4E-binding protein 1; PSA = prostate-specific antigen; and PI3K = phosphoinositide 3-kinase.
