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The effects of hypoxia or CoCl2 treatment on the CHKA and [18F]-D4-FCH uptake. (A) Immunoblots of the PC-3 and MDA-MB-231 cells under hypoxia (HC; <1% oxygen for 24 h) and CoCl2 (200 µM for 24 h). (B) One-hour cell uptake of [18F]-D4-FCH after the CoCl2 treatment.
