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. 2021 Aug 12;7(8):653. doi: 10.3390/jof7080653

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Histopathology findings of a section of small intestine: (A) HE stain (4×), within the necrotic areas, there are numerous fungal elements (arrows) invading all the layers beyond the mucosa. The fungi are characterised by thin walls and broad septate hyphae in keeping with basidiobolomycosis. (B) HE stain (40×), the fungal hyphae are associated with dense fibro-inflammatory reaction with numerous necrotising granulomas. In this image, a granuloma’s border is marked by asterisks. (C) HE stain (40×), hyphae are frequently surrounded by eosinophilic material known as Splendore–Hoeppli phenomenon (arrow). (D) GMS stain (20×), the fungi appear black with GMS stain (arrows). HE: haematoxylin and eosin; GMS: Gomori methenamine silver.