Figure 4.

SOX12 expression pattern and patient survival in various cancers. SOX12 expression pattern, alteration frequency of mutations, copy number alterations, and patient survival in various types of cancers. (a) Box plots comparing specific SOX12 expression in normal (left plot) and cancer tissues (right plot) were derived from the Oncomine database. The fold-changes in SOX12 expression in breast, esophageal, lung, and ovarian cancers and sarcoma were determined and are shown as box plots. (b) The mutations and alteration frequency of SOX12 were determined using the cBioPortal database. SOX12 mutation diagram of different cancer types across protein domains is shown. SOX11 mutation mainly occurred in bladder cancer with one hot spot (E294K) representing the common founder mutations. The alteration frequency of SOX12 was determined using the cBioPortal database and is shown at the bottom. Only cancer types containing more than 100 samples and an alteration frequency of >2.1% are shown. The alterations comprised deletions (blue), amplification (red), or mutation (green). (c) The survival plot comparing patients with high (red) and low (blue) expression in various cancer types was obtained using the Kaplan–Meier plotter, PrognoScan, and R2 databases. Survival plot analysis was performed using a threshold Cox p-value of <0.05. Abbreviations. IDC: invasive ductal carcinoma; OSE: ovarian surface epithelium; OVC: ovarian carcinoma; EAC: esophageal adenocarcinoma.