Figure 1.

Participant enrollment. Of the original 182 enrolled participants, a total of 137 patients were included in the analyses after 45 patients were excluded due to the appearance of exclusionary secondary diagnoses, missing data in the electronic medical record (EMR), or a change in primary diagnosis. Data analysis included n = 73 controls and n = 64 participants with CP. The number of female (F) and male (M) participants included in each cohort are indicated. All enrolled patients were utilized in the ROC dose analysis and for analyses comparing ROC dose against gestational data. Muscle sections from each diagnostic group were scanned for the presence of at least 10 nAChRs per section. Samples with fewer than 10 nAChRs per section were excluded from NMJ analysis.