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. 2021 Aug 3;11(8):765. doi: 10.3390/jpm11080765

Table 2.

Correlation of rocuronium with birth statistics and serum analytes.

Intubating Rocuronium Dose
Measure Reference Range Control Cerebral Palsy Not on CAT Cerebral Palsy on CAT
n Mean ± SEM Pearson r p Value n Mean ± SEM Pearson r p Value n Mean ± SEM Pearson r p Value
BW (kg) 1 2.5–4.0 44 3.53 ± 0.10 −0.166 0.281 24 1.58 ± 0.18 0.544 0.006 ** 29 2.58 ± 0.22 0.160 0.408
GA (weeks) 1 37–40 58 39.3 ± 0.31 −0.142 0.289 30 32.0 ± 0.90 0.416 0.022 * 32 35.3 ± 1.13 0.247 0.173
BW-by-GA 0.07–0.10 42 0.09 ± 0.00 −0.148 0.35 24 0.05 ± 0.00 0.510 0.011 * 29 0.07 ± 0.00 0.117 0.545
Serum ALT 2 0–35 U/L 0 NA NA NA 14 25.4 ± 2.10 0.286 0.322 29 26.8 ± 2.49 0.283 0.136
Serum Bilirubin 2 0.3–1.2 mg/dL 0 NA NA NA 14 0.54 ± 0.08 −0.062 0.833 29 0.27 ± 0.03 −0.153 0.427
Serum Mg 2 1.5–2.4 mg/dL 19 2.92 ± 0.19 0.255 0.291 4 3.27 ± 0.25 0.117 0.883 13 3.23 ± 0.30 −0.219 0.473
Serum Tri 2 <250 mg/dL 19 56.9 ± 11.1 −0.042 0.864 4 19.6 ± 10.3 −0.768 0.232 13 24.6 ± 6.60 0.032 0.918
Total Rocuronium Dose
Measure Reference Range Control Cerebral Palsy Not on CAT Cerebral Palsy on CAT
n Mean ± SEM Pearson r p Value n Mean ± SEM Pearson r p Value n Mean ± SEM Pearson r p Value
BW (kg) 1 2.5–4.0 44 3.53 ± 0.10 −0.166 0.281 24 1.58 ± 0.18 0.581 0.003 ** 29 2.58 ± 0.22 0.160 0.408
GA (weeks) 1 37–40 58 39.3 ± 0.31 −0.142 0.289 30 32.0 ± 0.90 0.432 0.017 * 32 35.3 ± 1.13 0.247 0.173
BW-by-GA 0.07–0.10 42 0.09 ± 0.00 −0.148 0.35 24 0.05 ± 0.00 0.555 0.005 ** 29 0.07 ± 0.00 0.117 0.545
Serum ALT 2 0–35 U/L 0 NA NA NA 14 25.4 ± 2.10 0.287 0.320 29 26.8 ± 2.49 0.454 0.013 *
Serum Bilirubin 2 0.3–1.2 mg/dL 0 NA NA NA 14 0.54 ± 0.08 −0.154 0.600 29 0.27 ± 0.03 0.040 0.837
Serum Mg 2 1.5–2.4 mg/dL 19 2.92 ± 0.19 0.259 0.285 4 3.27 ± 0.25 −0.573 0.427 13 3.23 ± 0.30 −0.051 0.869
Serum Tri 2 <250 mg/dL 19 56.9 ± 11.1 0.016 0.948 4 19.6 ± 10.3 −0.260 0.740 13 24.6 ± 6.60 −0.324 0.279

1 Nemours Kids Health, 2 Merck Manual; Pearson r statistic, p < 0.05 = *, p < 0.01 = **. Abbreviations: CAT = Chronic Anticonvulsant Therapy; SEM = Standard Error of Measurement; BW = Birth Weight; GA = Gestational Age; ALT = Alanine Transaminase; Mg = Magnesium; Tri = Triglycerides.