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. 2021 Aug 10;11(8):532. doi: 10.3390/metabo11080532

Table 2.

Anti-proliferative activity of the isolated metabolites from the sponge Theonella sp.

Compounds Cell Lines (IC50 μM)
MCF-7 MDA-MB-231 t-47D HCT-116 DLD-1 K562 Molt4
1 a a a a a 17.60 18.06
2 a a a a a a a
3 a a a 13.36 a 7.87 14.14
4 a a a a a a a
5 a a 18.08 a 2.50 10.93 8.61
6 a 5.98 a a a a a
7 1.03 a 0.65 0.78 0.55 0.01 0.02
Doxorubicin b 1.10 1.16 0.61 0.27 0.72 0.62 0.04

a IC50 > 20 μM; b positive control.