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Modified bidirectional permeability assay with Caco-2 cells. Data are mean values of duplicates. Final concentration of compounds in donor compartment was 1 µM.
| Compound | Caco-2 | Caco-2 in the Presence of Zosuquidar | ||||
|---|---|---|---|---|---|---|
|
Papp,AB (10−6 cm/s) |
Papp,BA (10−6 cm/s) |
Efflux |
Papp,AB (10−6 cm/s) |
Papp,BA (10−6 cm/s) |
Efflux | |
| Cyclosporin | 10 | 44 | 4.4 | |||
| Emodepside | 48 | 110 | 2.3 | 60 | 35 | 0.7 |
| BI-1 | 5 | 29 | 5.8 | 4.8 | 5.0 | 1.0 |
| BI-2 | 13 | 43 | 3.3 | 26 | 23 | 0.9 |
| BI-3 | 0.9 | 8.2 | 9.3 | 2.0 | 2.4 | 1.2 |
| BI-4 | 0.2 | 4.2 | 23.3 | 1.8 | 1.3 | 0.7 |
