Figure 6.

Evaluation of anti-TNF α Ab-CS/ PAMAM dendrimer NPs loaded-Ty-GG and Ty-GG/SF hydrogels effects under dynamic conditions. (a) Representative images of Dynamic culture of THP-1 cell-based inflammation in vitro model using a dual-chamber bioreactor showing the (I) dual-chamber bioreactor connected to a syringe pump; (II) higher amplification of the bioreactor inserted in a 6-well plate showing the piping tubes and collector tubes; and (III) enlarged image of the dual-chamber bioreactor where it is possible to see the upper and lower chamber. (b) Amount of TNF α present in the medium, in contact with C2 and C3 in static and dynamic conditions. Data shown as Mean ± SD. * indicates significant differences when comparing dynamic conditions with static conditions, Φ indicates significant differences when comparing with day 1.