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. 2021 Aug 17;13(8):1273. doi: 10.3390/pharmaceutics13081273

Table 4.

Proportions of isolates with in vitro reduced susceptibility to chloroquine, quinine, lumefantrine, desethylamodiaquine, pyronaridine, and piperaquine according to the pfcoronin genotype (P76 or 76S).

Drug (No Isolates) % of Isolates with Reduced Susceptibility (No of Isolates with Reduced Susceptibility/Total of Isolates) p-Value
(Chi-Squared Test)
Wild-Type Isolates (P76) Isolates with 76S Mutation
Chloroquine (328) 25.1 (70/279) 32.7 (16/49) 0.506
Quinine (325) 0 (0/276) 0 (0/49) 0
Lumefantrine (329) 0 (0/280) 0 (0/49) 0
Desethylamodiaquine (306) 8.0 (21/262) 9.1 (4/44) 1
Mefloquine (321) 23.4 (64/273) 29.2 (14/48) 0.631
Pyronaridine (319) 1.1 (3/273) 0 (0/46) 1
Piperaquine (321) 0.7 (2/273) 0 (0/48) 0.999