Table 4.
Proportions of isolates with in vitro reduced susceptibility to chloroquine, quinine, lumefantrine, desethylamodiaquine, pyronaridine, and piperaquine according to the pfcoronin genotype (P76 or 76S).
Drug (No Isolates) | % of Isolates with Reduced Susceptibility (No of Isolates with Reduced Susceptibility/Total of Isolates) |
p-Value (Chi-Squared Test) |
|
---|---|---|---|
Wild-Type Isolates (P76) | Isolates with 76S Mutation | ||
Chloroquine (328) | 25.1 (70/279) | 32.7 (16/49) | 0.506 |
Quinine (325) | 0 (0/276) | 0 (0/49) | 0 |
Lumefantrine (329) | 0 (0/280) | 0 (0/49) | 0 |
Desethylamodiaquine (306) | 8.0 (21/262) | 9.1 (4/44) | 1 |
Mefloquine (321) | 23.4 (64/273) | 29.2 (14/48) | 0.631 |
Pyronaridine (319) | 1.1 (3/273) | 0 (0/46) | 1 |
Piperaquine (321) | 0.7 (2/273) | 0 (0/48) | 0.999 |