Table 3.
Variations of QLQ-C30 questionnaires’ scores from baseline (T0) to T1-T4 in the Inositol Group and in the Control Group.
| All Participants N = 36 | Inositol Group N = 18 | p Value | Control Group N = 18 | p Value | ||
|---|---|---|---|---|---|---|
| QLQ-C30 Functional scales | ||||||
| Quality of life | T0 (baseline) | 54.2 (33.3; 58.3) | 66.7 (66.7; 83.3) | |||
| T1–T0 | 0.0 (0.0; 16.7) | 0.2168 | −33.3 (−41.7; −8,33) | 0.0001 | ||
| T2–T0 | 0.0 (−8.3; 16.7) | 0.5757 | −25.0 (−33.3; 0.0) | 0.0007 | ||
| T3–T0 | 0.0 (−16.7; 8.3) | 0.6797 | −33.3 (−50.0; −16.7) | 0.0001 | ||
| T4–T0 | 0.0 (−16.7; 16.7) | 0.9314 | −25.0 (−50.0; −16.7) | <0.0001 | ||
| Physical functioning | T0 (baseline) | 86.7 (73.3; 86.7) | 86.7 (80.0; 100.0) | |||
| T1–T0 | −3.3 (−20.0; 6.7) | 0.2507 | −26.7 (−40.0; −6.7) | <0.0001 | ||
| T2–T0 | 0.0 (−13.3; 20.0) | 0.7024 | −26.7 (−46.7; −6.7) | 0.0002 | ||
| T3–T0 | −10.0 (−26.7; 13.3) | 0.3068 | −43.3 (−46.7; −13.3) | <0.0001 | ||
| T4–T0 | −10.0 (−26.7; 13.3) | 0.106 | −46.7 (−66.7; −26.7) | <0.0001 | ||
| Role functioning | T0 (baseline) | 66.7 (50.0; 83.3) | 75.0 (66.7; 100.0) | |||
| T1–T0 | 0.0 (−16.7; 33.3) | 0.9204 | −16.7 (−33.3; 0.0) | 0.001 | ||
| T2–T0 | 0.0 (−16.7; 33.3) | 0.7852 | −16.7 (−33.3; 16.7) | 0.0347 | ||
| T3–T0 | −16.7 (−33.3; 16.7) | 0.3326 | −33.3 (−50.0; 0.0) | 0.0033 | ||
| T4–T0 | −16.7 (−33.3; 0.0) | 0.2574 | −33.3 (−66.7; −16.7) | 0.0003 | ||
| Cognitive functioning | T0 (baseline) | 83.3 (50.0; 100.0) | 100.0 (83.3; 100.0) | |||
| T1–T0 | 0.0 (−16.7; 16.7) | 0.9258 | −16.7 (−66.7; 0.0) | 0.002 | ||
| T2–T0 | 0.0 (−16.7; 0.0) | 0.4307 | 0.0 (−50.0; 0.0) | 0.0195 | ||
| T3–T0 | −8.3 (−33.3; 16.7) | 0.1913 | −25.0 (−50.0; 0.0) | 0.0029 | ||
| T4–T0 | 0.0 (−33.3; 16.7) | 0.2955 | −16.7 (−50.0; 0.0) | 0.001 | ||
| Social functioning | T0 (baseline) | 75.0 (66.7; 100.0) | 83.3 (66.7; 100.0) | |||
| T1–T0 | −8.3 (−16.7; 0.0) | 0.0508 | −16.7 (−33.3; 0.0) | 0.0005 | ||
| T2–T0 | −8.3 (−33.3; 0.0) | 0.1011 | 0.0 (−16.7; 0.0) | 0.0444 | ||
| T3–T0 | −16.7 (−50.0; 0.0) | 0.1653 | −25.0 (−50.0; 0.0) | 0.0034 | ||
| T4–T0 | −16.7 (−50.0; 0.0) | 0.139 | −33.3 (−50.0; 0.0) | 0.0017 | ||
| QLQ-C30 Symptom scales | ||||||
| Fatigue | T0 (baseline) | 33.3 (11.1; 44.4) | 16.7 (0.0; 33.3) | |||
| T1–T0 | 0.0 (−11.1; 33.3) | 0.2867 | 44.4 (0.0; 55.6) | 0.0002 | ||
| T2–T0 | 0.0 (−11.1; 33.3) | 0.2771 | 38.9 (0.0; 55.6) | 0.0007 | ||
| T3–T0 | 22.2 (−11.1; 33,.3) | 0.1015 | 44.4 (22.2; 66.7) | <0.0001 | ||
| T4–T0 | 16.7 (0.0; 33.3) | 0.0854 | 66.7 (22.2; 77.8) | <0.0001 | ||
| Nausea and vomiting | T0 (baseline) | 0.0 (0.0; 16.7) | 0.0 (0.0; 0.0) | |||
| T1–T0 | 0.0 (0.0; 33.3) | 0.2227 | 16.7 (0.0; 50.0) | 0.0059 | ||
| T2–T0 | 0.0 (0.0; 16.7) | 0.7070 | 8.3 (0.0; 33.3) | 0.0059 | ||
| T3–T0 | 0.0 (0.0; 16.7) | 0.9609 | 8.3 (0.0; 50.0) | 0.0322 | ||
| T4–T0 | 0.0 (−16.7; 0.0) | 0.6230 | 25.0 (0.0; 66.7) | 0.0022 | ||
| Dispnoea | T0 (baseline) | 0.0 (0.0; 33.3) | 0.0 (0.0; 33.3) | |||
| T1–T0 | 0.0 (0.0; 33.3) | 0.0625 | 0.0 (0.0; 33.3) | 0.0078 | ||
| T2–T0 | 0.0 (0.0; 33.3) | 0.0625 | 16.7 (0.0; 33.3) | 0.0137 | ||
| T3–T0 | 0.0 (0.0; 33.3) | 0.0156 | 33.3 (0.0; 33.3) | 0.002 | ||
| T4–T0 | 16.7 (0.0; 33.3) | 0.0215 | 33.3 (0.0; 33.3) | 0.0013 | ||
| Insomnia | T0 (baseline) | 0.0 (0.0; 66.7) | 33.3 (0.0; 33.3) | |||
| T1–T0 | 0.0 (0.0; 0.0) | 0.5703 | 16.7 (0.0; 66.7) | 0.0117 | ||
| T2–T0 | 0.0 (−33.3; 33.3) | 0.5820 | 16.7 (0.0; 66.7) | 0.0059 | ||
| T3–T0 | 0.0 (−33.3; 33.3) | 0.8621 | 0.0 (0.0; 66.7) | 0.0078 | ||
| T4–T0 | 0.0 (−33.3; 33.3) | 0.8267 | 33.3 (0.0; 66.7) | 0.0007 | ||
| Appetite loss | T0 (baseline) | 0.0 (0.0; 0.0) | 0.0 (0.0; 0.0) | |||
| T1–T0 | 0.0 (0.0; 33.3) | 0.6719 | 33.3 (0.0; 33.3) | 0.0471 | ||
| T2–T0 | 0.0 (0.0; 33.3) | 0.8281 | 0.0 (0.0; 33.3) | 0.2734 | ||
| T3–T0 | 0.0 (0.0; 0.0) | 0.8438 | 16.7 (0.0; 66.7) | 0.0156 | ||
| T4–T0 | 0.0 (0.0; 0.0) | 0.8828 | 50.0 (0.0; 66.7) | 0.0037 | ||