Table 2.
Area under the curve (AUC) comparing single-glycopeptide models, and group-glycopeptide models for the evaluation of cirrhosis and HCC samples. MVSHHN184LTTGATLINE = Asn184, NLFLN207HSE = Asn207, VVLHPN241YSQVDIGLIK = Asn241, and AFP = alpha-fetoprotein. Glycan nomenclature: HexNAc, Hex, Fuc, NeuAc (N-acetylhexosamine, hexose, fucose, N-acetylneuraminic acid, respectively).
| Single-Glycopeptide Model, Differentiation of Cirrhosis and HCC | |||
| Glycopeptide | AUC | CI 1 (Low) | CI 1 (High) |
| AFP | 0.85 | 0.72 | 0.97 |
| Asn207 + 5-6-1-2 isomer 2 | 0.81 | 0.65 | 0.97 |
| Asn207 + 5-6-1-3 isomer 1 | 0.85 | 0.72 | 0.99 |
| Asn207 + 5-6-1-3 isomer 2 | 0.83 | 0.68 | 0.98 |
| Asn207 + 5-6-0-1 isomer 2 | 0.77 | 0.59 | 0.95 |
| Asn207 + 5-6-0-2 isomer 1 | 0.58 | 0.58 | 0.93 |
| Asn207 + 6-7-1-1 isomer 3 | 0.81 | 0.66 | 0.97 |
| Asn241 + 4-5-0-0 | 0.79 | 0.62 | 0.96 |
| AFP “early HCC” | 0.81 | 0.57 | 1.00 |
| Asn207 + 5-6-0-1 isomer 2 “early HCC” | 0.88 | 0.65 | 1.00 |
| Group-Glycopeptide Model, Differentiation of Cirrhosis and HCC | |||
| Group of Glycopeptides | AUC | CI (Low) | CI (High) |
| AFP + (Asn207 + 5-6-1-2 isomer 2) | 0.88 | 0.75 | 1.00 |
| AFP + (Asn207 + 5-6-1-3 isomer 1) | 0.94 | 0.87 | 1.00 |
| AFP + (Asn207 + 5-6-1-3 isomer 2) | 0.93 | 0.85 | 0.99 |
| AFP + (Asn207 + 5-6-1-2 isomer 1) + (Asn207 + 5-6-1-3 isomers 1 and 2) | 0.98 | 0.93 | 1.00 |
| (Asn207 + 5-6-1-2 isomer 2) + (Asn207 + 5-6-1-3 isomers 1 and 2) | 0.87 | 0.74 | 0.99 |
| Sialylated Fucosylated in Asn207 | 0.91 | 0.80 | 1.00 |
| Sialylated Fucosylated in Asn207 + Sialylated Fucosylated in Asn184 | 0.91 | 0.79 | 1.00 |
1 Confidence interval (95%).