Scheme 1.
Synthesis of 3-(2-oxoquinolin-1(2H)-ylamino)-3-arylacrylic acid (4 and 5). Reagents and reaction condition: (i) CH3COCH2COOEt, conc H2SO4, (ii) N2H4, pyridine; (iii) Ar-CH=CH-COOH, NaOAc, (iv) Br2, AcOH.
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