Table 1.

In vitro antitumor activity of quinolone derivatives 3, 4a,b and 5a,b over MCF-7, HepG2 and HCT-116, cell lines. Data are expressed as the mean ± SD.

Comp No.	IC50 (μM)
	MCF-7	HepG2	HCT-116
3	32.9 ± 1.81	8.23 ± 0.42	15.0 ± 0.79
4a	18.7 ± 1.03	19.4 ± 0.99	21.3 ± 1.12
4b	11.8 ± 0.65	15.5 ± 0.79	7.56 ± 0.4
5a	19.3 ± 1.06	4.05 ± 0.21	1.89 ± 0.10
5b	8.48 ± 0.47	30.9 ± 1.57	10.7 ± 0.57
STU	6.91 ± 0.38	5.23 ± 0.27	4.25 ± 0.22