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. 1999 Mar;19(3):2155–2168. doi: 10.1128/mcb.19.3.2155

FIG. 8.

FIG. 8

PAb421 influences p53 exonuclease and sequence-specific DNA binding activities in opposite manners. Metal affinity-purified full-length p53 was incubated with increasing amounts of PAb421 and tested for exonuclease activity (A, lanes 2 to 7) or sequence-specific DNA binding (B). p53 was also incubated with a non-p53-specific antibody (PAb108, specific for SV40 T-Ag) and tested for exonuclease activity (A, lanes 8 to 13).