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. 2021 Aug 11;11(8):784. doi: 10.3390/jpm11080784

Figure 1.

Figure 1

The connected folate, methylation, and redox cycles. Ovals represent enzymes and boxes represent metabolites. Red indicates metabolites and enzymes repeatedly noted to be consistently abnormal in ASD. Green highlights treatments that improve the metabolism of these cycles. Folic acid is shown in yellow as it is a suboptimal treatment because it is oxidized and has to be converted to active forms of folate.