Fig. 6.

Serpine1 is downregulated by circ-GALNT16 and has a connection with CRC progression. a, b. Heatmap and scatter diagram showed the RNA-seq result in circ-GALNT16 overexpression and control RKO cells. c. Several candidates were validated by qRT-PCR. d, e. The mRNA and protein levels of Serpine1 in circ-GALNT16 knockdown and overexpression cells. f. Correlation analysis between circ-GALNT16 and Serpine1. (R = -0.3106, P = 0.0125) g-j. Serpine1 expression in CRC and the correlation with relative clinical features analysis from TCGA. All data are presented as the means ± SD of three independent experiments. ^nsp > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001