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. 2021 Jul 31;13(8):1188. doi: 10.3390/pharmaceutics13081188

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Dissolution profiles of nanocrystal dispersions (F5, F6, and F8), corresponding suspensions (S5, S6, and S8) and coarse DK-I-60-3 (p < 0.05: F5 vs. S5 (20 min), F5 vs. S5 (60 min); F6 vs. S6 (20 min), F6 vs. S6 (60 min), F6 vs. S6 (8 h); F8 vs. S8 (60 min), F8 vs. S8 (2 h), F8 vs. S8 (8 h); F5 vs. F6 (4 h), F5 vs. F6 (8 h); F6 vs. F8 (4 h), F6 vs. F8 (8 h); F5 vs. DK (20 min); F6 vs. DK (20 min), F6 vs. DK (2 h), F6 vs. DK (4 h), F6 vs. DK (8 h); F8 vs. DK (8 h), Univariate ANOVA); (b) solubility of DK-I-60-3 in nanocrystal dispersions (F5, F6, and F8) and corresponding suspensions (S5, S6, and S8) in different media at 37 °C.