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. Author manuscript; available in PMC: 2021 Aug 28.
Published in final edited form as: Pediatr Res. 2020 Jul 29;89(6):1549–1556. doi: 10.1038/s41390-020-1093-1

Table 3.

The main effects of maternal rs35331017, maternal stress and their interaction effects on spontaneous PTB in the mothers from the Boston Birth Cohort and from the GPN study

Variable BBC discovery an=1,484b GPN Replication cAfrican-American Mothers n=337 GPN Replication cCaucasian Mothers n=738
OR 95% CI P OR 95% CI P OR 95% CI P
rs35331017 3.51 1.98–6.22 1.73×10−5 45.6 0.43–482.0 0.108 4.35 1.18–16.5 0.030
Perceived stress 1.44 1.19–1.75 1.75×10−4 1.76 1.14–2.71 0.010 1.78 1.35–2.56 0.0005
rs35331017×stress interaction d 0.14 0.07–0.28 4.7×10−8 0.12 0.01–1.37 0.088 0.46 0.20–0.86 0.023

BBC: Boston Birth Cohort; CI: confidence interval; GPN: Genomic and Proteomic Network for Preterm Birth Research; PTB: preterm birth; OR: odds ratio.

a

The analysis was conducted using the logistic regression model, adjusted for genotyping batch, maternal genetic ancestry, age at delivery, marital status, parity, social support from the baby’s father and newborn sex in the BBC discovery sample.

b

n=1484 after removing 6 mothers with missing genotypic data on rs35331017.

c

The analysis was conducted using the logistic regression model, adjusted for genetic ancestry, maternal age at enrollment, parity, marital status and newborn sex in the GPN replication sample.

d

Here P value for the interaction effect was estimated using an interaction term of maternal stress and the 35331017 genotype (under an additive genetic model).