Table 6.
The changes of fecal weight, total cholesterol, and triglyceride levels in SD rats fed different experimental diets for 6 and 11 weeks.
| Diet | C | CS | DM | DM + TZD | DM + CS |
|---|---|---|---|---|---|
| 6 weeks | |||||
| Feces wet weight (g/day) | 1.9 ± 0.34 | 2.4 ± 0.37 * | 2.0 ± 0.43 | 2.1 ± 0.18 | 2.7 ± 0.57 # |
| Feces dry weight (g/day) | 1.7 ± 0.27 | 2.1 ± 0.34 * | 1.7 ± 0.32 | 1.9 ± 0.15 | 2.2 ± 0.35 # |
| Total cholesterol | |||||
| (mg/g feces) | 17.1 ± 3.4 | 31.4 ± 8.4 * | 17.6 ± 6.5 | 17.7 ± 3.0 | 31.4 ± 6.6 # |
| (mg/day) | 28.5 ± 7.3 | 64.0 ± 17.8 * | 31.4 ± 15.2 | 34.0 ± 7.0 | 67.6 ± 11.3 #@ |
| Triglyceride | |||||
| (mg/g feces) | 3.4 ± 0.35 | 5.1 ± 1.3 * | 4.3 ± 0.83 | 4.9 ± 1.1 | 6.5 ± 1.4 # |
| (mg/day) | 5.7 ± 1.3 | 10.4 ± 2.8 * | 7.6 ± 2.4 | 9.2 ± 1.6 | 14.0 ± 2.4 #& |
| 11 weeks | |||||
| Feces wet weight (g/day) | 1.6 ± 0.24 | 3.2 ± 0.61 * | 1.6 ± 0.34 | 1.9 ± 0.36 | 2.9 ± 0.61 # |
| Feces dry weight (g/day) | 1.1 ± 0.26 | 2.7 ± 0.63 * | 1.1 ± 0.31 | 1.5 ± 0.36 | 2.3 ± 0.69 # |
| Total cholesterol | |||||
| (mg/g feces) | 24.3 ± 6.6 | 31.7 ± 7.1 * | 20.2 ± 5.0 | 19.8 ± 5.8 | 29.3 ± 6.2 #@ |
| (mg/day) | 26.9 ± 11.3 | 86.6 ± 27.1 * | 23.4 ± 10.5 | 29.3 ± 12.5 | 69.0 ± 28.3 #@ |
| Triglyceride | |||||
| (mg/g feces) | 10.9 ± 1.5 | 15.0 ± 3.0 * | 12.2 ± 2.3 | 12.8 ± 3.6 | 15.9 ± 3.3 #@ |
| (mg/day) | 12.0 ± 3.5 | 41.0 ± 11.6 * | 13.5 ± 3.5 | 18.5 ± 5.7 | 36.5 ± 12.3 #@ |
Results are expressed as mean ± SD for each group (n = 8). The significant difference (p < 0.05) was analyzed by one-way ANOVA and two-tailed Student’s t-test. *: versus C; #: versus DM; &: versus CS; @: versus DM + TZD. C: control diet; CS: control diet + 5% high molecular weight chitosan; DM: diabetes + control diet; DM + TZD: diabetes + control diet +0.8 mg/kg thiazolidinediones; DM + CS: diabetes + control diet + 5% high molecular weight chitosan.