Figure 5.

Early TUDCA treatment preserved ERG OPs in diabetic mice. (A) With early treatment, OP2 amplitudes at 8 weeks post-STZ were similar between groups. (B) With late treatment, OP2 amplitudes at 8 weeks post-STZ were similar between all treatment groups. (C) With early treatment, OP2 implicit times at 8 weeks were significantly delayed in the DM+Veh group at the two dimmest flash stimuli compared to DM+TUDCA (two-way repeated measures ANOVA F_12,212 = 3.541, interaction effect p < 0.001). (D) With late treatment, OP2 implicit times were similar for all groups. (E) With early treatment, OP2 implicit times were plotted for 4 and 8 weeks post-STZ and the slope of the change calculated. While the DM+Veh group had a positive slope, the DM+TUDCA group was negative. (F) In the late treatment group, the slope of the OP2 implicit times were reduced, but still showed a similar trend, with the slope of the DM+Veh group having positive values and the DM+TUDCA group having negative values. Holm–Sidak post hoc comparisons indicated by asterisks: * p <0.05, ** p <0.01; n.s. = not significant.